Hi guys, I'm not new to the emu scene, but I have never tried to run anything like PCSX2 on my Mac.

MBP - 2.4GHz Intel C2D, 2GB DDR2. MacOSX 10.5.8 (Leopard, not "Snow Leopard")

I think I've got everything operational, I've dumped the BIOS from one of my two PS2s, I've configured the plugins (as far as I can figure). I have one of my PlayStation2 discs in the drive, and when I go to Run - CD/DVD, I can run the PlayStation "OS" but get no audio, and it does not see a disc to run.

What am I doing wrong?

might be some detection problems with the disc(don't know) ... anyway try making an iso image of your game(with imgburn or something else) and set the "cdvdrom" plugins to "linuz iso" then select your iso, after that file/ run cd/dvd. that should do the trick
edit:sorry , didn't read that this thread was in the mac support section so don't know if it works for mac(don't know anything about mac)

AFAIK ImgBurn is a Win-only software. I'll try with a Mac equivalent.

PS, next time I'll try to be more clear that this pertains to Mac.

There is no real disk cdvd plugin, so only isos are supported