well, semevral things can cause it to crash. 3 things to try:
1: defrag your computer then try it again.
2: run a disc check on the hard drive with pcsx2 on it (not always the main hard drive for everyone) , again, run it, see if it crashes. (disc check will take 30-45 MINUTES, so find something else to do in the meantime)
3: try redownloading the emu, and reconfigure it?