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How do you change multiple game ISO(CDs) and what is the plugin to use for?

Most of those games (if not all) let you save to memory card before you switch the discs, so you should be able to boot the second disc and just load your memcard save to continue without a problem.

Do you have a problem with a game in particular?

Well, Actually I had backed up a game before which I bought which is in 2 DVD or so I think Star Ocean Till the End of Time... I don't really play it yet but ahh, I will try playing it till disc 2 and I will revive the thread until then if I run to some problems with games. I was just wondering, That's all. Thanks.

You shouldn't have a problem with that game then.