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It seems the positioning of the "cursur/pointer" in some games like Rez, and Okami (in "paint" mode) is skewed a little relative to the center of the screen. It has not always been like this in Rez until recently, and Im not sure whether it's something about changes in my OS or just some settings in PCSX2.
I've provided some screenshots as example

Wild guess: Widescreen hacks enabled?

A wild and correct guess thx.

Har, epic. If I dare say so myself