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I read through the sticky posts and did a search and still can't find what I am looking for. I am sure this question has been asked 1000 times and I am sorry to ask it again. I downloaded the .pnach file for a game I am playing. Placed it in the Cheats folder and Enabled Cheats after the game was loaded. I can't figure out how to actually activate the cheats. Thanks for your help ahead of time!

it should automatically be activated if you've placed it right and you activated cheats.

Normally you only need to take the slashes (//) in front of the actual cheats away...

//pnach,1,.... => pnach,1,...

Is the pnach file named correctly? It should have the CRC of the game you want them to activate in the name.