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When i want to change my GS, these logs showed up:
[wx] Failed to load shared library 'C:\Program Files\PCSX2 1.2.1\Plugins\gsdx32-avx-r5875.dll' (error -1073741795: unknown error c000001d)
Path: C:\Program Files\PCSX2 1.2.1\Plugins\gsdx32-avx-r5875.dll
File is not a valid dynamic library.
Some kinda plugin failure: C:\Program Files\PCSX2 1.2.1\Plugins\gsdx32-avx-r5875.dll
[wx] Failed to load shared library 'C:\Program Files\PCSX2 1.2.1\Plugins\gsdx32-avx2-r5875.dll' (error -1073741795: unknown error c000001d)
Path: C:\Program Files\PCSX2 1.2.1\Plugins\gsdx32-avx2-r5875.dll
File is not a valid dynamic library.
Some kinda plugin failure: C:\Program Files\PCSX2 1.2.1\Plugins\gsdx32-avx2-r5875.dll

I wanted to change my GS to gsdx32-avx-r5875 but due to this error, i can't change it.
Please help!!

Your CPU probably doesn't support the instruction set

With other words just select the highest instruction set your cpu supports. (Probably SSE4.1)