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Just asking. Let's say for a instance, i want to play GTA San Andreas on PCSX2. But also want to use any kind of mod (like superman mod) to be used in. would it actually work?

Or any homebrew games would work in if maded by someone?

If the mod was designed for the PS2 I see no reason why it wouldn't work
and yes PCSX2 started out playing homebrew games

Nice!