Ratchet and Clank: Up Your Arsenal

[jesalvein]

not really, since optimizing is most of the time suing speedhacks and/or setting extra sw rendering threads.
the compatibility list may help you find some special settings to workaround some bugs, though

[Blyss Sarania]

It really depends on your machine. Most games won't need the kind of tweaking that R&C does. Most of them will run just fine on these settings(based on your machine):

Speedhacks: Default + MTVU (Don't use MTVU for any games on this list: http://forums.pcsx2.net/Thread-LIST-Game...-with-MTVU )

GSdx settings:
Direct3d 11 hardware
3x native resolution
16x anisoptropic filtering
texture filtering: checked
Optional: Enable HW hacks, click configure, set MSAA at the top to 4x. (This will screw the graphics up in a handful of games, but otherwise will make the polys smoother)

Any game that needs special settings, you can usually find such settings in the game's thread here: http://forums.pcsx2.net/Forum-Public-compatibility-list