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I'm playing FFX and the sound comes in too early and I see the mouths move when there's no sound and it's out of sync. Most of the time the game runs at 60 FPS even during cut-scenes. What's the best sound plugin to use and what options should I have checked?
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You disabled time stretching. Enable it

Also your speedhack settings are way too extreme. Expect all kinds of bugs with that.

I'm pretty sure SPU-X is the best bet for compatibility. I usually only check the first box for the small speedup, and leave the drag-down menus to 1.

Though if that still has troubles, give Zerospu a shot.