I downloaded and installed all the relevant software but when i try to open the application, it just shrugs and tells me to go f*** myself (figuratively; it just opens and closes immediately).
Did you make sure to download the Snow Leopard pkg file (
http://pcsx2mac.net/files/pcsx2SL.pkg )? I downloaded the older one first and it didn't work for me, but the SL one did.
If so, need more info before we can know how to fix your problem.