Sry to bump an old thread, but any resolution on this? It happens to me too, quite often a different .dll being unloaded. Only started after updating to 4600 and continues in 4866. Ripped a few old ps2 games, and it seems to happen on all the games.
It's a driver-OS issue and certainly not PCSX2 so I don't think we can be of much help
ok will reupdate all the drivers, thanks
an update, following another guy's post earlier from another topic (couldn't find it to thank the guy), changing the spu-x audio to directsound seems to have worked for me.