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What game are you playing?

Call of Duty: Finest Hour.

Did you change to Iso in CDVD?
If you did but this still happen,then try the latest SVN...i think you should post your program log in order to everyone can see your problem.

what ISO loading type you are using Directly?,Linuz-ISO? or CDVDolio?

in addition show us your emulog.txt after that loading error

are you using fast boot or full boot? if you are using full, try using fast.

@refraction

It works with fast boot. Thanks.