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I am using opengl hardware and I am trying to enable the accurate blend and accurate color clip settings but they will not stay on. When I close out of the plugin settings window they automatically turn off again. Any help with this would be greatly appreciated.

run pcsx2 in administrator mode, and make sure pcsx2 is NOT installed is C:\Program Files (x86) or C:\Program Files

If have like 2nd HDD i recommend putting on that drive.

I hope you pressed "OK" and not "Cancel", right ?