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I use PS2 Emulator on a laptop, (Toshiba Satellite P50-B-11U) and i use PS2 disc with PS2 Emulator but game sometimes frozen because my CDROM sometimes stopped working CDROM really sometimes sleeps and wake ups again. I try to say with my bad english, CDROM not working stable, on all game discs with PS2 emulator. How i fix this problem? CDROM needs working never stop... :/ CDROM sometimes stops and emulator frozes every 10 second.

That's exactly why we recommend making an iso image.
use imgburn to do so

Souns like there's something wrong with your disc drive. Either that or it's got some energy saving setting that stops it from spinning for too long.