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Trying to change the texture offsets as per the "known issues" section of this wiki page: https://wiki.pcsx2.net/Shin_Megami_Tense...sona_3_FES
But every advanced setting is greyed out and unusable. My emulator is the latest stable version and every setting is default. Why are the options greyed out and how do I fix it?

uncheck "preset" at the bottom

You need to tick "enable hw hacks" first

Didn't see a "preset" button but "enable hw hacks" worked, thanks!