how to make pcsx2 autorun iso

[nosisab Ken Keleh]

It's complicated for PCSX2 is not a game, to make it work as you want you need to copy the iso file itself as a shortcut to desktop and associate .iso with PCSX2. that will work but be aware all and every ISO file will try to open PCSX2 if clicked.

PS: make sure you have "Iso" and not plugin set under the CDVD tab.

If you do as said above, ISO files will get a nice PCSX2 icon, you can change it for the desktop game's shortcut if you have a sample.

To change the application to start that kind of file, right click any .iso file (the game's disk image itself does the trick), click the button "properties" and
at "Open with" click change and navigate to your active PCSX2 directory and click the executable.

BUT, having a shortcut to PCSX2 on the desktop and starting games from the gui using Iso (and not plugin and having to mount isos in virtual drivers) is cleaner and very easy.

[vsub]

Why associate?
You can just create a shortcut which contains this in the target
"path to pcsx2.exe" "path to the game image"

You can even add --nogui command line so the game will start like pc game(without the gui)...but be aware that using --nogui will make the Esc key close pcsx2 completely.

"path to pcsx2.exe" --nogui "path to the game image"

[nosisab Ken Keleh]

Why associate?
You can just create a shortcut which contains this in the target
"path to pcsx2.exe" "path to the game image"

You can even add --nogui command line so the game will start like pc game(without the gui)...but be aware that using --nogui will make the Esc key close pcsx2 completely.

"path to pcsx2.exe" --nogui "path to the game image"

Indeed.

Just that in this case the workload is much greater than just having the PCSX2 itself and doing the last recommendation in my previous post.

the association is done once and is valid for all (provided the OP does not use to click ISOs to open something else).