When I start pcsx up the ps2 output screen says this.
NTFS Compression Enable > Permission Denied to file or stream
Filename: memcards
NTFS Compression Enable > General Win32 File/stream error [GetLastError: 6]
PCSX2 0.9.6 - compiled on Feb 27 2009
Savestate version: 8b400004

This seems to make it unable to save any configuration changes I make. What can I do to fix this? I run windows vista by the way in case that helps.

Maybe someone has asked this before...Perhaps reading recent posts would tell you how to fix this. Like the one two posts down entitled "What am I doing wrong?"

Perhaps with run as administrator at. Pcsx2 exe file can solve this problem?

Or maybe disable the "Enable NTFS compression" in Memcards

but that wouldn't solve the config's not saving, so run as admin would be the thing to do